Publications by authors named "S Sanjose"
Background: This study was conducted to evaluate screening procedures for anal high-grade squamous intraepithelial lesions (HSILs) with anal liquid-based cytology (aLBC) and biomarkers to identify candidates for high-resolution anoscopy (HRA).
Methods: This cross-sectional study included men who have sex with men with HIV. Participants underwent HRA, aLBC, and biomarker testing.
: Implementing self-sampling (SS) in cervical cancer screening requires comparable results to clinician-collected samples (CCS). Agreement measures are essential for evaluating HPV test performance. Previous studies on non-paired samples have reported higher viral cycle threshold (Ct) values in SS compared to CCS, affecting sensitivity for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+).
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- HPV genotype plays a crucial role in predicting cervical cancer risk, and using genotyping can improve management strategies for HPV-positive patients during cervical screening.
- The ScreenFire HPV RS assay, combined with the Zebra BioDome technology, facilitates efficient testing by processing up to 96 samples in about an hour while minimizing contamination risks with fewer pipetting steps.
- Validation studies on the Zebra BioDome showed excellent repeatability and accuracy when compared to the standard assay, suggesting it could streamline HPV testing and improve accessibility for point-of-care diagnostics in low-resource settings.
Background: Research in children is essential for them to benefit from the outcomes of research but involvement must be weighed against potential harms. In many countries and circumstances, medical research legally requires parental consent until the age of 18 years, with poorly defined recommendations for assent prior to this. However, there is little research exploring how these decisions are made by families and the ethical implications of this.
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- Mixed carcinomas, which represent about 10% of penile carcinomas, consist of multiple distinct histological subtypes, categorized by the World Health Organization (WHO) into two groups based on their HPV association.
- The study aimed to detect HPV genotypes in these mixed tumors, revealing a higher HPV positivity rate (46%) in carcinomas with warty/basaloid features compared to a low rate (7%) in non-warty/basaloid types.
- HPV16 was the most commonly identified genotype (65%), and the presence of HPV-associated morphology above 20% in mixed tumors is critical for classification as HPV-associated, in accordance with WHO guidelines.