Publications by authors named "S Sanaz Ramezanpour"
Article Synopsis
- A biocompatible polyelectrolyte complex (PEC) was created using Tragacanth gum (TG) and chitosan (CS) to explore its potential biological applications, with an optimized TG:CS ratio of 18:2 identified through various tests.
- The study found that at pH 4, TG and CS showed strong interactions, highlighting charge neutralization in the PECs, which featured a unique macroporous structure.
- The PEC cryogel demonstrated significant antibacterial activity against E. coli and S. aureus, while also promoting wound healing in human fibroblast cells without any toxic effects.
An efficient strategy for passive delivery of doxorubicin (DOX) to the breast (MDA-MB-231) and lung (A-549) cancer cells is presented and compared with MCF-10A normal breast cells. Two versions of a peptide structure (linear and cyclic) have been designed and assessed. The molecular dynamic simulations in Material Studio2017 exhibited a higher adsorption capacity for L (cyclic version) compared with the adsorption capacity of L (linear version) on the PG surface by electrostatic interactions between guanidine of arginine and -OH of PG.
View Article and Find Full Text PDFA practical approach for rapid and efficient access to spirocyclic isobenzofurans is described. The reaction proceeds through the cycloaddition of 1,6-ynenone derivatives and 4-nitro-1,3-diarylbutan-1-ones, promoted by CsCO in the presence of -proline as a catalyst. The advantages of this reaction include the formation of two C-C bonds and one C-O bond as well as mild reaction conditions.
View Article and Find Full Text PDFThe prevalence of breast cancer underscores the imperative for early diagnosis in guiding treatment decisions. This study introduces a novel contrast agent, Gd-DTPA-VGB3, derived from the peptide VGB3 targeting vascular endothelial growth factor receptor-1 (VEGFR1) and VEGFR2, to enhance the contrast of conventional drug Magnevist in breast tumor MRI. The MRI contrast agent was synthesized on rink amide resin via Fmoc strategy, incorporating amino acids, and coupling to diethylenetriaminepentaacetic acid (DTPA).
View Article and Find Full Text PDFRationale And Objectives: The number of international medical graduates (IMGs) entering radiology residencies and neuroradiology fellowships averaged 9.7% and 20.9% from 2021 to 2023, respectively.
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