Publications by authors named "S Sanatani"
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, potentially life-threatening genetic heart disease. Nonselective beta-blockers (BBs) are highly effective in reducing CPVT-triggered arrhythmic events. However, some patients suffer from unacceptable BB side effects and might require strategies without a BB.
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- * Researchers identified 21 human ITPR1 GOF variants and created a mouse model with one of these variants (ITPR1-W1457G), which was found to be prone to stress-induced ventricular arrhythmias.
- * Both mouse models and human data suggest that ITPR1 GOF variants increase Ca handling abnormalities and arrhythmia risk, with 7 rare ITPR1 variants in a human database showing similar GOF behavior linked to cardiac
Article Synopsis
- The study aimed to clarify the roles, responsibilities, and qualifications of pediatric cardiology chiefs by surveying those currently in the position across North America, addressing a gap in the literature.* -
- A total of 62% of pediatric cardiology chiefs participated in a mixed-methods survey, revealing key attributes necessary for the role, including communication skills, honesty, and conflict resolution, while also highlighting concerns about administrative demands and a lack of diversity.* -
- The findings emphasize the importance of communication and mentorship in leadership roles and suggest that future research should explore broader perspectives, including faculty and international viewpoints.*
Article Synopsis
- There is a significant lack of expertise in managing pediatric arrhythmias in low- and middle-income countries (LMIC), creating a need for better education.
- Children's Heartbeat is a virtual program designed to connect pediatric electrophysiologists with clinicians in these under-resourced areas, offering monthly case-based discussions to enhance skills in arrhythmia management.
- The initiative has successfully increased participation and confidence among healthcare providers, with plans to expand its reach to more medical trainees and evaluate the program's impact on patient care in LMIC.