Electrochemical oxygen activation driven by enamine-keto push-pull interactions in triazole-based covalent organic polymers.

We have developed two triazole-based covalent organic polymers (COPs) with donor-acceptor motifs. The keto-enriched COP demonstrated exceptional oxygen activation electrochemical stimuli, driven by strong push-pull interactions. studies and DFT calculations confirmed the critical role of enamine carbon positive charges in enhancing performance, setting new benchmarks in COP design.

Coordination Structure Modulation in Group-VIB Metal Doped AgPO Augments Active Site Density for Electrocatalytic Conversion of N to NH.

Doping is considered a promising material engineering strategy in electrochemical nitrogen reduction reaction (NRR), provided the role of the active site is rightly identified. This work concerns the doping of group VIB metal in AgPO to enhance the active site density, accompanied by d-p orbital mixing at the active site/N interface. Doping induces compressive strain in the AgPO lattice and inherently accompanies vacancy generation, the latter is quantified with positron annihilation lifetime studies (PALS).

Lewis Acid Mediated Alteration of Electron Density on a Copper Site via pπ-dπ Mixing Enhances the Electrochemical Nitrogen Reduction Reaction.

Strategic modulation of the electronic structure of the catalyst to foster the electrochemical nitrogen reduction reaction (eNRR) to the ammonia process significantly is still an area that needs to be explored. Herein, we report the incorporation of the Lewis acid into an electron-rich copper site regulating the electron density of the metal, which has been experimentally proved from the d-band center position to have a direct influence on the adsorption of N compared to the protons. The catalyst boron doped copper-cuprous oxide hybrid system (B-Cu/CuO) has shown promising Faradaic efficiency of 32% at -0.

designed aliphatic and aromatic peptides assemble into amyloid-like cytotoxic supramolecular nanofibrils.

Peptides are very interesting biomolecules that upon self-association form a variety of thermodynamically stable supramolecular structures of nanometric dimension nanotubes, nanorods, nanovesicles, nanofibrils, nanowires and many others. Herein, we report six peptide molecules having a general chemical structure, H-Gaba-X-X-OH (Gaba: γ-aminobutyric acid, X: amino acid). Out of these six peptides, three are aromatic and the others are aliphatic.

Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.

Upregulation of utrophin, the autosomal homologue of dystrophin, can compensate dystrophin deficiency in Duchenne Muscular Dystrophy (DMD) although the therapeutic success is yet to be achieved. The present study has identified Poly (C) binding protein 2 (PCBP2) as a post-transcriptional suppresser for the expression of utrophin-A, the muscle-specific utrophin isoform. This study confirms nuclear retention of utrophin-A mRNA in C2C12 cells, which is mediated by PCBP2.