Publications by authors named "S Sakano"
Data on the C-reactive protein (CRP) flare response in patients with metastatic and unresectable urothelial carcinoma (mUC) are limited. The present study aimed to clarify the clinical significance of the CRP flare response in patients with mUC who received pembrolizumab. Between March 2018 and December 2022, patients with mUC who received pembrolizumab following chemotherapy were retrospectively reviewed.
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- A study examined the effectiveness of avelumab and pembrolizumab, treatments for metastatic urothelial carcinoma post-chemotherapy, focusing on factors predicting patient outcomes.
- The research included 243 patients, analyzing characteristics and blood data to identify independent prognostic factors like performance status and specific blood markers.
- Findings indicate a new risk score utilizing platelet-to-lymphocyte ratio and lactate dehydrogenase levels could effectively predict overall survival after starting immune checkpoint inhibitors, outperforming existing models.
Article Synopsis
- A study examined the effectiveness of avelumab maintenance therapy compared to pembrolizumab in patients with metastatic and unresectable urothelial carcinoma after 4 cycles of chemotherapy without disease progression.
- Data from 243 patients treated between January 2017 and December 2022 was analyzed, with a focus on oncological outcomes and adverse events using a method called propensity score matching.
- The findings indicated that both avelumab and pembrolizumab had similar progression-free survival rates, but avelumab required a lower rate of high-dose glucocorticoid treatment.
(-)-FR901483 () isolated from the fungus sp. No.11231 achieves immunosuppression via nucleic acid biosynthesis inhibition rather than IL-2 production inhibition as accomplished by FK506 and cyclosporin A.
View Article and Find Full Text PDFObjectives: The number of patients receiving antiplatelet therapy (APT) who have undergone laparoscopic radical nephrectomy is increasing. However, it is unclear whether APT affects the outcomes of patients undergoing radical nephrectomy. We investigated the perioperative outcomes of radical nephrectomy in patients with and without APT.
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