Publications by authors named "S Sakaguchi"
Helicobacter pylori possesses an intrabacterial nanotransportation system (ibNoTS) for transporting VacA, CagA, and urease within the bacterial cytoplasm. This system is controlled by the extrabacterial environment. The transport routes of the system for VacA have not yet been studied in detail.
View Article and Find Full Text PDFArticle Synopsis
- Oceanic islands are valuable for studying plant ecology and evolution, particularly through cases like Callicarpa glabra, Callicarpa parvifolia, and Callicarpa subpubescens, which are native to the Ogasawara Islands.
- These species exemplify evolutionary changes such as adaptive radiation and dioecious sex expression, making them ideal candidates for understanding genetic relationships and colonization processes.
- Phylogenomic analysis revealed that these species share a common ancestor with East Asian plants, having diverged about three million years ago, likely due to long-distance dispersal from East Asia followed by speciation on the islands.
Article Synopsis
- The tumor microenvironment (TME) has immune-suppressive cells, particularly T helper 1-polarized regulatory T cells (T1-T cells), but little is known about their abundance.
- Research shows that depleting arginase I-expressing tumor-associated macrophages (Arg1 TAMs) can decrease tumor growth and reduce the presence of T1-T cells.
- Arg1 TAMs produce platelet factor 4 (PF4), which promotes T1-T cell polarization via specific receptors, and targeting PF4 can limit T1-T cell accumulation and aid in fighting tumors.
Exploring the hidden world of RNA viruses with a transformer-based tool.
Patterns (N Y)
November 2024
Hou and He et al. developed a new RNA virus identification tool named LucaProt, a transformer-based bioinformatics software using sequence and structural characteristics of RNA-dependent RNA polymerases (RdRPs), which are essential for almost all RNA viruses. LucaProt can identify RdRPs from highly diverse RNA viruses, unveiling the hidden RNA virosphere.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2, the virus responsible for COVID-19, has led to significant global disruptions and has prompted the rapid development of various drugs and vaccines to combat it.
- The virus's ability to mutate has resulted in new variants that may diminish the effectiveness of current treatments.
- Electron microscopy, particularly through techniques like transmission electron microscopy (TEM) and electron tomography (ET), is invaluable for studying the virus's replication and different particle types, which could assist in developing new antiviral treatments.