Publications by authors named "S Sahi"
Pancreatic cancer, with a 5-year survival rate below 10 %, is one of the deadliest malignancies. The TGF-ß pathway plays a crucial role in this disease, making it a key target for therapeutic intervention. Clinical trials targeting TGF-β have faced challenges of toxicity and limited efficacy, highlighting the need for more potent small molecule inhibitors.
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- - The study evaluated the safety and effectiveness of semaglutide, a diabetes and weight loss medication, in patients with advanced chronic kidney disease (CKD) stages 4 and 5, as well as those on dialysis, due to limited existing research in this area.
- - Data from 76 patients (mostly males with a mean age of 66.8) was analyzed over approximately five years, showing significant weight loss (avg. drop of 4.9 kg) and decreased hemoglobin A1c levels (avg. drop from 8.0% to 7.1%).
- - While 63.1% reported no adverse effects, the most common issues leading to discontinuation were nausea, vomiting,
Brown spot of citrus caused by Alternaria citri is one of the emerging threats to the successful production of citrus crops. The present study, conducted with a substantial sample size of 50 leaf samples for statistical reliability, aimed to determine the change in mineral content in citrus leaves after brown spot disease attack. Leaf samples from a diverse range of susceptible citrus varieties (Valentia late, Washington navel, and Kinnow) and resistant varieties (Citron, Eruka lemon, and Mayer lemon) were analyzed.
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- - The study analyzes the outcomes of kidney transplant candidates with obesity who underwent sleeve gastrectomy (SG) to qualify for transplantation, showing significant weight loss post-surgery.
- - Among 54 patients who had SG, 37% were listed for a kidney transplant, and 20 received a transplant, compared to lower rates in a nonsurgical group (14% listed, 10% transplanted).
- - While SG resulted in effective weight loss and improved transplant rates, it also carried risks of complications and functional decline, indicating a need for further safety and efficacy research.