Publications by authors named "S SPITZ"
Article Synopsis
- There is an increasing interest in vasectomies following the Supreme Court's Dobbs decision, highlighting their safety and cost-effectiveness compared to tubal sterilization.
- Health care providers from Title X-funded clinics were interviewed to understand the cultural, gender, and political influences on men's decisions to seek vasectomies.
- Key barriers identified included income challenges, language barriers, medical distrust, and traditional gender roles, but many men expressed a strong desire to take responsibility for contraception and contribute to reproductive health equity.
Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limited penetration depth within 300 μm, largely due to light scattering. Here, we demonstrate that the imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues by adopting multimode fiber-based, low repetition rate, high peak power, three-photon excitation of NAD(P)H at 1100 nm.
View Article and Find Full Text PDFParkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in vitro models are enabling the study of the dopaminergic neurons' loss, but not the dysregulation within the dopaminergic network in the nigrostriatal pathway. Additionally, these models do not incorporate aging characteristics which potentially contribute to the development of Parkinson's disease.
View Article and Find Full Text PDFThe blood-brain barrier (BBB) serves as a selective filter that prevents harmful substances from entering the healthy brain. Dysfunction of this barrier is implicated in several neurological diseases. In the context of Alzheimer's disease (AD), BBB breakdown plays a significant role in both the initiation and progression of the disease.
View Article and Find Full Text PDFArticle Synopsis
- * A 2022 needs assessment utilized both quantitative and qualitative data from 145 leaders of such organizations to investigate access to funds, finding that many organizations faced challenges in securing grants due to lack of training and non-inclusive language in funding proposals.
- * Despite no statistical differences in funding applications and success rates between organizations serving BIPOC vs. non-Hispanic White communities, there were still notable instances of inequitable funding outcomes, suggesting systemic issues that need further exploration.