Prior Emergency Department Utilization Association With Nonaccidental Trauma in Children.

Introduction: Physical child abuse (PCA) is believed to occur in an escalating manner with multiple episodes occurring over time. This pattern may potentially lead to multiple emergency department (ED) visits, often to different EDs. The aim of this study was to evaluate prior ED utilization as a risk factor for PCA in children.

The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo.

The microenvironment is a rich source of new cancer targets. We thus used a targeted single-guide RNA library to screen a panel of human pancreatic cancer lines for genes uniquely affecting tumorigenesis. Here we show inactivation of the Adapter Protein complex-2 of clathrin-mediated endocytosis reduces cell growth in vitro, but completely oppositely, promotes tumor growth in vivo.

Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.

Introduction: We evaluated the independent associations between high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels with Alzheimer's disease and related dementias (ADRD).

Methods: Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs and HDL-C conditional on age, sex, and body mass index. We included these residuals individually and concurrently in Cox models predicting ADRD incidence.

Allelism of Uncharacterized Dwarf Mutants in Maize.

Gibberellic acid (GA) is a phytohormone that is important for plant growth and development. Mutants in GA biosynthesis, signaling and metabolism have been critical to understanding the role GA plays in plants. GA mutants have also revolutionized global production of staple crops such as rice, wheat, and barley.

Two new positive psychosocial measures for persons living with dementia.

Introduction: Differences in adaptive strategies used by individuals and families living with dementia have the potential to impact day-to-day well-being. The Living Well Inventory for Dementia (LWI-D) is a new measure to capture these strategies and to illuminate new options to support families living with dementia. The Quality of Day Scale (QODS) is a new measure to capture global well-being in persons based on a shorter temporal frame than traditional quality of life measures.