Accuracy of radiologists and radiology residents in detection of paediatric appendicular fractures with and without artificial intelligence.

Objectives: We aim to evaluate the accuracy of radiologists and radiology residents in the detection of paediatric appendicular fractures with and without the help of a commercially available fracture detection artificial intelligence (AI) solution in the hopes of showing potential clinical benefits in a general hospital setting.

Methods: This was a retrospective study involving three associate consultants (AC) and three senior residents (SR) in radiology, who acted as readers. One reader from each human group interpreted the radiographs with the aid of AI.

Factors associated with emergency department methicillin-resistant Staphylococcus aureus coverage in patients with skin and soft tissue infections in an urban, tertiary care emergency department.

Introduction: Skin and soft tissue infections (SSTIs) are common and contribute significantly to morbidity and healthcare costs in emergency departments (EDs). The rise of antimicrobial resistance, particularly due to community-acquired methicillin-resistant Staphylococcus aureus (MRSA), complicates treatment decisions. Objective physical examination findings suggesting need for empiric MRSA coverage are sometimes ignored.

Comparing quality and barriers to sleep in non-mechanically ventilated intensive care patients in intensive care unit and in hospital ward.

Purpose: It is uncertain if quality and barriers of sleep differs based on the location of a patient in the hospital. Our aim was to compare the patient reported sleep quality (QoS) in non-mechanically ventilated patients in ICU and wards, and identify the barriers of sleep in ICU and in wards.

Methods: The survey assessed the QoS at three stages including the day immediately prior to hospital admission, after their last night spent in the ICU prior to discharge, and the first night in wards.

TNO155 is a selective SHP2 inhibitor to target -dependent oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is known to be driven by multiple intricated receptor tyrosine kinases (RTKs) including EGFR, PI3K/AKT and MAPK signaling pathways. However, whilst targeting EGFR with cetuximab has been approved for the treatment of OSCC, other single-agent inhibitors of the RTKs have shown modest effects in improving survival. From the genome-wide CRISPR/Cas9 screen on 21 OSCC cell lines, we have identified among the top essential genes in OSCC.