Multi-objective collaborative optimization of active distribution network operation based on improved particle swarm optimization algorithm.

ADN (Active distribution network) is easily disturbed during its operation, resulting in problems such as power supply quality degradation and operation safety deterioration. Therefore, the research and simulation of multi-objective collaborative optimization of ADN operation based on improved particle swarm optimization algorithm are proposed. An objective function of multi-objective collaborative optimization configuration for ADN operation is constructed.

Neurodegenerative diseases: Epigenetic regulatory mechanisms and therapeutic potential.

Neurodegenerative diseases (NDDs) are a class of diseases in which the progressive loss of subtype-specific neurons leads to dysfunction. NDDs include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), among others. Previous studies have demonstrated that the pathogenesis of NDDs involves various mechanisms, including genetic factors, oxidative stress, apoptosis, and the immune response.

Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency.

Background: Oxidative stress is a significant cause in the occurrence of cardiac insufficiency. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase2 (NOX2)-derived reactive oxygen species (ROS) play a pivotal role in oxidative stress-induced excitation-contraction decoupling. Stachydrine hydrochloride (Sta) reduces pressure overload-induced cardiac insufficiency, which may be related to the NOX2-ROS pathway, as demonstrated by our earlier research.