Publications by authors named "S S Tuncer"
The efficacy of MitoTEMPO, a mitochondria-targeted antioxidant, in altering nerve fiber conduction properties within the sciatic nerve of streptozotocin (STZ)-induced diabetic rats, a model for diabetic neuropathy characterized by myelinated fiber atrophy and nodal abnormalities. Utilizing the STZ-induced diabetic rat model, we assessed the impact of MitoTEMPO on nerve function through compound action potential (CAP) analysis and histological evaluation. Key indicators such as maximum depolarization (MD), CAP area, and conduction velocity distribution (CVD) were measured to gauge MitoTEMPO's neuroprotective effects, alongside physical parameters like weight and blood glucose levels.
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- * Using techniques like Next-Generation Sequencing (NGS) and RT-PCR, researchers found that four variants were pathogenic and affected splicing, while three did not have any significant impact.
- * The findings underscore the need for experimental validation of splice-site variants, as they may influence genetic disorders and cancer risk, calling for further research into alternative splicing to explore potential therapies for cancer.
A rare paraneoplastic condition in Hodgkin lymphoma: Evans syndrome and literature review.
North Clin Istanb
October 2024
Article Synopsis
- Evans syndrome (ES) is a combination of autoimmune blood disorders, primarily autoimmune hemolytic anemia and immune thrombocytopenia, which can occasionally be secondary to other conditions like Hodgkin lymphoma (HL).
- A case study is presented of a 56-year-old male diagnosed with both ES and HL; treatments like corticosteroids, IVIG, and ABVD successfully resolved his immune cytopenias.
- The literature review indicated 16 other cases of HL and ES occurring together, highlighting the complexity of their relationship and the variable treatment responses, particularly when an underlying condition is present.
Objectives: This study aimed to evaluate the 18-month clinical performance of two different one-step adhesives that were applied alone or with an additional hydrophobic adhesive layer to noncarious cervical lesions.
Methods And Materials: One hundred sixty teeth in 31 patients were included in the study. Each patient received at least four restorations.
Article Synopsis
- Optic pathway gliomas (OPG) are rare tumors in children, with factors like lesion extent, visual function, and neurofibromatosis 1 (NF1) influencing treatment decisions; a study evaluated treatment and outcomes of 95 patients over 31 years.
- The first-line treatment for most patients was a one-year chemotherapy regimen of vincristine and carboplatin, avoiding radiotherapy unless necessary, with many patients showing stable disease without treatment.
- Overall survival rates were high among patients (97.2% at ten years), but progression-free survival was significantly better in those with NF1, highlighting the effectiveness of chemotherapy and the potential to avoid radiotherapy in these patients.