Publications by authors named "S S Toldo"

A plastic optical fiber (POF)-based device for biosensing strategies has been developed to monitor several protein-protein interactions at ultra-low concentrations without functionalization processes, exploiting plasmonic phenomena. In this work, novel tests were applied to different kinds of analyte-receptor interactions, such as interleukins, where the bioreceptor's (protein antibody) molecular weight is roughly ten times that of the analyte (protein interleukin), while intracellular bioreceptors and small molecules at low molecular weight interactions have already been demonstrated via the same point-of-care test (POCT). The POCT was implemented by a white light source and a spectrometer connected via two POF-based chips connected in series: an innovative microcuvette chip and a D-shaped POF surface plasmon resonance (SPR) probe.

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Article Synopsis
  • A new color-based, semi-automatic algorithm was developed to detect, isolate, and quantify myocardial infarction in cardiac tissues using four histological staining methods.
  • The algorithm identifies differences in color between infarct and non-infarct regions, demonstrating effectiveness with staining techniques like Masson's trichrome and hematoxylin and eosin.
  • It shows promise for accurately quantifying both infarct regions and diffuse fibrosis in cardiac tissues, enhancing evaluation of therapeutic strategies for heart diseases.
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Tobacco addiction is the primary preventable factor contributing to global mortality, and nicotine is one of the substances with the greatest potential for addiction. With a strong affinity for the α4β2 subtype receptor, cytisine (CYT) functions as a partial agonist of the acetylcholine nicotinic cholinergic receptor. It counteracts the effects of nicotine without causing any withdrawal symptoms.

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