Publications by authors named "S S Somkuwar"

Background: The black fungus, mucormycosis, is on the list of lethal complications reported in recent times in COVID patients.

Methodology: This cross-sectional study included all cases of post-COVID-19 mucormycosis. Patients' demographics, clinical presentations, and general health information were collected using a pre-designed form.

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Purpose: Polymethylmethacrylate denture bases are prone to fracture, so reinforcement of dentures with nanoparticles is required to overcome these challenges. This invitro study was done to assess the effect of reinforcement with nanoparticles of polyetheretherketone (PEEK), zirconium oxide (ZrO2) and its mixture on flexural strength of polymethylmeythacrylate resin.

Materials And Methods: A total of 60 acrylic resin specimens measuring 65 mm × 10 mm × 2.

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Article Synopsis
  • Angiogenesis, or the growth of new blood vessels, is important for maintaining balance in the brain, and previous studies showed increased angiogenesis markers in rats during recovery from alcohol dependence.
  • Systemic injections of the angiogenesis inhibitor endostatin reduced the likelihood of relapse to drinking in female rats but not in males, and it did not affect relapse to sucrose drinking in either sex.
  • Endostatin also affected various cellular processes in the prelimbic cortex, with distinct impacts on neuroimmune and synaptic changes between genders, suggesting a new approach to treating alcohol relapse, particularly in females.
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Previous studies demonstrate that ethanol dependence induced by repeating cycles of chronic intermittent ethanol vapor exposure (CIE) followed by protracted abstinence (CIE-PA) produces significant alterations in oligodendrogenesis in the rodent medial prefrontal cortex (mPFC). Specifically, CIE-PA produced an unprecedented increase in premyelinating oligodendroglial progenitor cells and myelin, which have been associated with persistent elevated drinking behaviors during abstinence. The current study used neuroimaging and electron microscopy to evaluate the integrity of enhanced myelin and microstructural deficits underlying enhanced myelination in the mPFC in male rats experiencing forced abstinence for 1 day (D), 7D, 21D and 42D following seven weeks of CIE.

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This study sought to determine if reducing dopamine D1 receptor (D1R) expression in the dorsal striatum (DS) via RNA-interference alters methamphetamine self-administration. A lentiviral construct containing a short hairpin RNA (shRNA) was used to knock down D1R expression (D1RshRNA). D1RshRNA in male rats increased responding for methamphetamine (i.

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