Publications by authors named "S S Soldan"
Epstein-Barr virus (EBV) is a ubiquitous human ɣ-herpesvirus implicated in various malignancies, including Burkitt's lymphoma and gastric carcinomas. In most EBV-associated cancers, the viral genome is maintained as an extrachromosomal episome by the EBV nuclear antigen-1 (EBNA1). EBNA1 is considered to be a highly stable protein that interacts with the ubiquitin-specific protease 7 (USP7).
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- The study investigates how patients with hypertension perceive the differences between their self-reported medication adherence and the actual adherence confirmed by chemical testing, revealing a disconnect between perception and reality.* -
- Thirteen patients underwent interviews that highlighted six themes related to their feelings and reactions to adherence testing, including frustration, discomfort, shame, and a desire for communication with healthcare providers.* -
- The findings suggest that clinicians should recognize the varying emotional responses to nonadherence and improve communication strategies to better support patients in managing their hypertension.*
Epstein-Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis (MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well understood. Here we characterized spontaneous lymphoblastoid cell lines (SLCLs) isolated from MS patients and healthy controls (HC) ex vivo to study EBV and host gene expression in the context of an individual's endogenous EBV.
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- Aberrant splicing of the MS4A1 gene results in multiple mRNA isoforms of CD20, with V1 and V3 being the most significant in B-cell malignancies and immune responses.
- The presence of V3 correlates with higher CD20 protein levels, while V1 is likely translation-deficient due to structural elements that inhibit protein synthesis.
- Studies show that modulating these isoforms can enhance CD20 expression and improve the effectiveness of anti-CD20 therapies, highlighting a potential link between splicing patterns and immunotherapy resistance.
Article Synopsis
- The gene encoding CD20 in human B cells produces multiple mRNA isoforms, particularly V1 and V3, which play different roles in B-cell malignancies and immunotherapy responses.
- Increased CD20 positivity during B-cell activation correlates with the shift from V1 to V3, and only V3 is associated with higher CD20 protein levels in diffuse large B-cell lymphoma.
- Manipulating CD20 isoform expression can enhance the effectiveness of anti-CD20 therapies, revealing that splicing changes may contribute to resistance in immunotherapy, particularly evident in relapsed follicular lymphoma cases.