Acta Medica (Hradec Kralove)
November 2023
The study sought to evaluate the influence of anesthesia on chronic pain after total knee arthroplasty (TKA). : This was a single-center, randomized controlled study, with patients receiving a spinal anesthetic (SP) alone or a general anesthetic (GA) with femoral block, with follow-up at 3 and at 6 months. The primary outcome was the WOMAC score at 6 months.
View Article and Find Full Text PDFThe current paper describes the performance of a commercial-scale (20,000 tpa) demonstration facility of the DiCOM process, a biological treatment for the organic fraction of municipal solid waste (OFMSW). The 21-d process combines aerobic composting and high-solids (30%DM), thermophilic (55 °C) anaerobic digestion (AD), within a single vessel. Mechanically sorted OFMSW, derived from mixed household MSW (324 t), was exposed to sequential aerobic/anaerobic/aerobic treatment.
View Article and Find Full Text PDFProtein kinases are important enzymes in solid tumour and leukaemia pathologies. Their structures are well understood at the atomic level and their key role in the progression of certain cancers makes them valuable targets for anti-cancer therapy. Through medicinal chemical approaches, we developed an efficient preparative stereospecific synthesis of N12, N13 pyran-bridged indolocarbazoles that opens access to functional diversity within this previously challenging series.
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