Publications by authors named "S S Sait"
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexisting benign lesions called plexiform neurofibromas (PNs). PNs are solely driven by biallelic loss eliciting RAS pathway activation, and they respond favorably to MEK inhibitor therapy.
View Article and Find Full Text PDFAllergic rhinitis (AR) is a common chronic condition characterized by nasal congestion, sneezing, and itching, which significantly impacts quality of life. Traditional treatments, including antihistamines and intranasal corticosteroids, often fall short in managing moderate-to-severe cases. Recently, biologic therapies such as omalizumab and dupilumab have emerged as potential alternatives.
View Article and Find Full Text PDFBackground: Communication impairments significantly impact the quality of life for individuals with Parkinson's disease (PD), underscoring the need for effective interventions. Singing, by engaging shared neural networks and structural mechanisms involved in speech production, holds therapeutic potential for addressing speech disorders in this population. This study explores the effects of singing-based therapeutic intervention on voice in patients diagnosed with PD.
View Article and Find Full Text PDFBackground: Chronic rhinosinusitis affects a large portion of the adult population, and its symptoms can be burdensome to patients' quality of life. Functional endoscopic sinus surgery (FESS) is usually required after medical therapies fail.
Objective: To analyze the outcomes of FESS in a tertiary hospital using the modified Arabic Sinonasal Outcome Test.
Article Synopsis
- The prognosis for patients with central nervous system retinoblastoma (RB) after high-dose chemotherapy and stem cell transplant remains poor, and the effects of radiation therapy used afterward are unclear.
- A study reviewed data from 16 patients with CNS RB who received chemotherapy followed by high-dose stem cell transplant, observing a 75% response rate to initial treatment.
- Patients who received radiation therapy post-transplant had a 62.5% survival rate at 5 years, while those who did not only had a 28.6% survival rate, suggesting that radiation could improve outcomes and warrants further clinical trials.