Impact of extended lairage periods on physio-metabolic status and meat quality in commercial broilers.

1. This study investigated the impact of different lairage duration on physiology, metabolism and meat quality in commercial broilers.2.

Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway Inhibition.

Although targeted MAPK pathway inhibition has achieved remarkable patient responses in many cancers, the development of resistance has remained a critical challenge. Adaptive tumor response underlies the drug resistance. Furthermore, such bypass mechanisms often lead to the activation of many pro-survival kinases, which complicates the rational design of combination therapies.

Heat stress in dairy animals and current milk production trends, economics, and future perspectives: the global scenario.

Animal's well-being, growth, and production are modulated by environmental conditions, and managemental practices and can be deleteriously affected by global warming phenomenon. In the recent years, unprecedented climatic fluctuations like sustained higher temperatures and humidity, heat waves, and solar flares have led to economic losses in $ billions to both milk and meat industry. It is estimated that by 2050, the US dairy industry alone will borne more than $1.

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood.