Publications by authors named "S S Poulsen"
Article Synopsis
- The study aimed to evaluate the effects of trimetazidine, an antianginal medication, on heart function in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt).
- Twenty-two participants were enrolled in a randomized, double-blind trial, comparing the effects of trimetazidine to a placebo over four weeks, measuring various cardiovascular and mitochondrial functions.
- The results showed no significant improvements in key cardiac measures, such as pulmonary artery wedge pressure or mitochondrial function, indicating that trimetazidine did not provide benefits to patients with ATTRwt compared to the placebo.
Introduction: In order to identify the efficacy of treatment interventions for trauma-affected refugees follow-up studies are highly warranted. Hence, the overall aim of this study was to examine the effi-cacy of sleep-enhancing treatment, IRT and mianserin, in a sample of 219 trauma-affected refugees at six-month follow-up post-treatment.
Methods: Data were derived from a four-armed randomized controlled trial in a sample of trauma-affected refugees with PTSD.
Article Synopsis
- Gremlin-1 has been linked to liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) by inhibiting BMP signaling, making it a potential focus for therapy.* -
- In studies using rat and human models, blocking Gremlin-1 with antibodies did not reduce liver inflammation or fibrosis, despite its increased presence in specific myofibroblast cells.* -
- Findings indicate that Gremlin-1 does not significantly contribute to liver fibrosis development and is not a viable target for treatment due to its limited role in the disease process.*
Article Synopsis
- This study investigated how TNF-α inhibitor adalimumab affects inflammation and mitochondrial function in adipose tissue in patients with hidradenitis suppurativa (HS) after 12 weeks of treatment.
- Findings showed that while patients had a greater presence of anti-inflammatory macrophages, treatment did not significantly change overall adipose tissue inflammation or mitochondrial respiration.
- Additionally, patients experienced improved quality of life scores, even though clinical symptoms remained unchanged.