A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line.

Introduction: The changes in histone modifications are linked to the progression of benign and normal tissue to malignancy. Thus, numerous findings suggest that targeting epigenetic factors might be a focus for anti-cancer treatment. In this study, we tested the hypothesis that telomerase activator might be a potential epigenetic regulator in combatting skin cancer cell proliferation.

Rationally designed Cu(II) Schiff base metal complex anchored on NiFeO@chitosan: an efficient heterogeneous and magnetically retrievable hybrid nanocatalyst for the one-pot multi-component synthesis of bioactive 1-amidoalkyl-2-naphthols.

We reported, herein, the fabrication of a Cu(II) Schiff base metal complex, immobilized on chitosan surface coated on NiFeO MNPs, intended as a novel heterogeneous and magnetically recyclable nanocatalyst, NiFeO@CS@CuSB. The synthesis process starts with the preparation of NiFeO MNPs followed by coating with chitosan and then subsequent immobilization of the Cu(II) Schiff base metal complex on its surface. Through comprehensive characterization of the prepared nanocatalyst using FT-IR, PXRD, SEM, EDS, TEM, SAED, VSM, BET, XPS, and ICP-AES, the structure, surface morphology, elemental composition, and characteristics of the catalyst are revealed.

Effectiveness of educational training program on the knowledge of COTPA Act among the nonteaching staff of a tertiary care hospital.

Background: Globally, tobacco is among the leading factors attributable to death. The nonteaching staff plays a pivotal role in making a campus a "tobacco-free zone." The objective of the study is to assess the effectiveness of an educational training program conducted on the Cigarette and Other Tobacco Products Act (COTPA) 2003 among nonteaching staff of a tertiary care hospital.

Immune-checkpoint HLA-G gene polymorphisms, 3'-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population.

Background: Human leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3'-UTR of the HLA-G gene that may alter its expression, identify risk alleles and genotypes for their association with hepatocellular carcinoma (HCC), and treatment responses in the Indian population.

Objectives: Case-control genetic association study of HLA-G gene UTR polymorphisms with HCC and response to locoregional therapy (LRT).

Water source, latrine type, and rainfall are associated with detection of non-optimal and enteric bacteria in the vaginal microbiome: a prospective observational cohort study nested within a cluster randomized controlled trial.

Background: Less than one-third of sub-Saharan Africans have access to improved water sources. In US, Indian, and African studies, Bacterial vaginosis (BV) is increased among women with poor water, sanitation, and hygiene (WASH). We examined water source, sanitation (latrine type), and rainfall in relation to the vaginal microbiome (VMB).