Synthesis of chitosan succinate-g-amine functionalized mesoporous silica: Inorganic-organic nanohybrid for antibacterial assessment, antioxidant activity and pH-controlled drug delivery.

An innovative and proficient inorganic-organic nanohybrid was synthesized by using amine modified MCM-41 as an inorganic precursor combined with organic moiety, a derivative of chitosan i.e. chitosan succinate through amide bond.

Designing quorum sensing inhibitors of utilizing FabI: an enzymic drug target from fatty acid synthesis pathway.

infections are a leading cause of death in patients suffering from respiratory diseases. The multidrug-resistant nature of is potentiated by a process known as quorum sensing. The aim of this study was to reveal new inhibitors of a well-validated but quite unexplored target, enoyl-ACP reductase, which contributes acyl chain lengths of -acyl homoserine lactones that are major signaling molecules in gram-negative bacteria.

Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa.

Aims: Pseudomonas aeruginosa is a well-known pathogen responsible for various infections due to its capability to develop biofilm and various virulent phenotypes that are regulated by quorum sensing. Pathogenesis of the bacteria may be halted by interfering with the signaling molecules and the quorum sensing receptors. Therefore, the present study explores the potential of parthenolide, a sesquiterpene lactone of feverfew plant, as a promising candidate against P.

Cu(II)-carboxymethyl chitosan-silane schiff base complex grafted on nano silica: Structural evolution, antibacterial performance and dye degradation ability.

O-Carboxymethyl chitosan (OCMC) Schiff's base was utilized for a new class of organic-inorganic hybrid material by grafting it on nano-silica-silane and further metallated with Cu (II). Here (3-Aminopropyl) triethoxysilane (APTES) was used as a linker and 2-hydroxy-1-naphthaldehyde (HN) for Schiff's base formation. The hybrid was characterized by FTIR, TGA, powder XRD, SEM, CHN, DLS, ICP-AES, diffuse reflectance UV-vis and EDX spectroscopic techniques.

Structure based virtual screening for identification of potential quorum sensing inhibitors against LasR master regulator in Pseudomonas aeruginosa.

Inter and intracellular communication in bacteria, which is known as quorum sensing (QS), is mediated by small diffusible signaling molecules known as autoinducers. QS regulates various virulence factors responsible for pathogenesis. Increasing resistance of microorganisms against traditional antibiotics has turned the focus towards the QS as it exerts less selective pressure preventing development of resistance among microorganisms.