NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth.

Purpose: Advanced prostate cancer (PCa) is invariably fatal with the androgen receptor (AR) being a major therapeutic target. AR signaling inhibitors have improved overall survival for men with advanced PCa, but treatment resistance is inevitable and includes reactivation of AR signaling. Novel therapeutic approaches targeting these mechanisms to block tumor growth is an urgent unmet clinical need.

Fully Endoscopic Microvascular Decompression of the Trochlear Nerve for Treatment of Medically Refractory Superior Oblique Myokymia: Technical Case Instruction and Operative Video.

Background And Importance: We describe, to our knowledge, the first report of fully endoscopic microvascular decompression (MVD) of the trochlear nerve in a patient with superior oblique myokymia (SOM).

Clinical Presentation: A 51-year-old female presented with multiple years of intermittent, "jumpy," and "shimmering" visual disturbances. She was diagnosed with SOM.

Contrasting Responses to Ethenylbenzene (Styrene) and 2-Ethyl-1-hexanol Suggest their Role as Chemical Cues in Host Selection by the Seed Beetle Zabrotes subfasciatus (Coleoptera: Chrysomelidae: Bruchinae).

Seed beetles spend most of their lives within the seeds of host plants belonging to the Fabaceae family. Evidence suggests the cues that mediate pre-oviposition behaviour in Zabrotes subfasciatus (Boheman) are volatile organic compounds (VOCs) emitted by the seeds and suggests differential abilities in environment sensing between sexes. Here, we tested whether VOCs from different legume species trigger different levels of attraction, whether females and males differ in their ability to respond to VOCs, and whether the seeds promoting different behaviours feature singular VOCs.