Publications by authors named "S S Mick"
High-resolution cryo-electron microscopy (cryo-EM) requires costly 200- to 300-keV cryo-transmission electron microscopes (cryo-TEMs) with field emission gun (FEG) sources, stable columns, constant-powered lenses, autoloader, and direct electron detectors (DED). Recent advances in 100-keV imaging with the emergence of sub-200-keV optimized DED technology promises the development of more affordable cryo-TEMs. So far, 100-keV imaging has required microscopes with FEG sources.
View Article and Find Full Text PDFExons within transcripts are traditionally classified as first, internal or last exons, each governed by different regulatory mechanisms. We recently described the widespread usage of 'hybrid' exons that serve as terminal or internal exons in different transcripts. Here, we employ an interpretable deep learning pipeline to dissect the sequence features governing the co-regulation of transcription initiation and splicing in hybrid exons.
View Article and Find Full Text PDFFundamental quantum phenomena in condensed matter, ranging from correlated electron systems to quantum information processors, manifest their emergent characteristics and behaviors predominantly at low temperatures. This necessitates the use of liquid helium (LHe) cooling for experimental observation. Atomic resolution scanning transmission electron microscopy combined with LHe cooling (cryo-STEM) provides a powerful characterization technique to probe local atomic structural modulations and their coupling with charge, spin and orbital degrees-of-freedom in quantum materials.
View Article and Find Full Text PDFMaximizing Minimally Invasive Cardiac Surgery With Enhanced Recovery (ERAS).
Innovations (Phila)
November 2024
Article Synopsis
- A group of heart surgeons and doctors met to talk about how to improve a special type of heart surgery called minimally invasive cardiac surgery (MICS).
- They want to make sure the surgery uses smaller cuts to make recovery easier for patients while still achieving good results.
- They believe that to get the best results from MICS, there should be three key parts: smaller surgical cuts, proper care of the heart during surgery, and a program called Enhanced Recovery After Surgery (ERAS) that helps patients heal better afterward.
Article Synopsis
- Recent advancements in mechatronics have led to the development of advanced arm prostheses, but challenges remain in designing effective control schemes, particularly for those with higher levels of impairment.
- Current commercial options are limited in versatility and customization, pushing researchers to use specialized lab apparatus for testing new innovations.
- The Smart Arm platform was created as a customizable, multi-articulated robotic arm prosthesis that supports research on control and sensory feedback, demonstrating notable success in practical applications like the Cybathlon event.