Publications by authors named "S S Lightman"
Cortisol is released upon activation of the hypothalamic-pituitary-adrenal axis, varies across the day, possesses an underlying diurnal rhythm and is responsive to stressors. The endogenous circadian peak of cortisol occurs in the morning, and increases in cortisol observed post-awakening have been named the cortisol awakening response (CAR) based on the belief that the act of waking up stimulates cortisol secretion. However, objective evidence that awakening induces cortisol secretion is limited.
View Article and Find Full Text PDFPurpose: Evaluation of longer-term effectiveness of three intravitreal therapies (methotrexate, ranibizumab, or dexamethasone implant) for participants enrolled in the randomized comparative effectiveness trial the Macular Edema Ranibizumab versus Intravitreal anti-inflammatory Therapy (MERIT) Trial followed for24 weeks.
Design: Multicenter randomized controlled clinical trial with masked evaluation of retinal thickness and visual acuity.
Participants: Patients with persistent or recurrent uveitic macular edema.
Article Synopsis
- - Mineralocorticoid (MR) and glucocorticoid receptors (GR) are key transcription factors involved in various processes like stress response, hormonal signalling, mood, cognition, and memory, despite their structural differences, especially in the N-terminal domain.
- - A study using a Proximity Ligation Assay (PLA) on murine neuroblastoma (N2A) cells showed that continuous stimulation with corticosterone (CORT) results in MR-GR complexes accumulating at the cell nucleus's periphery, particularly when the receptor's ligand binding domain is truncated.
- - Interestingly, while MR-GR complex localization changed with receptor activation, there wasn't a straightforward link between where these complexes were located in the nucleus and
Aims: To determine the impact of microorganism virulence on visual outcomes in endophthalmitis.
Methods: Retrospective, multicentre cohort study of patients presenting with endophthalmitis between 2006 and 2021. A literature review was conducted to divide cultured microorganisms into low and high virulence subcategories.
Selye described stress as a unified neurohormonal mechanism maintaining homeostasis. Acute stress system activation is adaptive through neurocognitive, catecholaminergic, and immunomodulation mechanisms, followed by a reset via cortisol. Stress system components, the sympathoadrenomedullary system, hypothalamic-pituitary-adrenal axis, and limbic structures are implicated in many chronic diseases by establishing an altered homeostatic state, allostasis.
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