Publications by authors named "S S Lele"
Advanced prostate cancer (PCa) remains a significant clinical challenge, and docetaxel plays a significant role in disease management. Despite the efficacy of docetaxel as a first-line chemotherapy, resistance often develops. We developed three clinically relevant in vitro PCa cell models and transcriptomic analysis identified that the Paf1/RNA polymerase II complex component (PAF1)-associated pluripotent-transcription factor (TF), SOX2, plays a crucial role in docetaxel resistance.
View Article and Find Full Text PDFA Rare Case of Giant Cystic Adenomatoid Tumor of the Uterus With Literature Review.
Case Rep Obstet Gynecol
October 2024
Adenomatoid tumors are rare benign neoplasms arising from mesothelial cells, commonly found in the female genital system, particularly the uterus and fallopian tubes. The giant cystic variant of adenomatoid tumor is exceptionally rare and can cause massive growth mimicking malignant gynecological conditions. Histology and immunohistochemistry play a crucial role in confirming the diagnosis, with markers such as calretinin, D2-40, CK7, BAP1, ER, and WT1 proving useful.
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- Linezolid, a commonly used antibiotic, can cause rare side effects like teeth discoloration, which isn't widely known compared to more familiar reactions like nausea or bone marrow suppression.
- A case study reveals that a child treated with linezolid for bacterial meningitis developed brownish teeth discoloration, which was temporary and resolved after stopping the medication.
- This instance highlights the need for awareness of lesser-known side effects of medications and suggests that teeth discoloration can occur earlier than previously documented.
Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regions that have not been linked to spinal cord biology.
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- * t-NEPCs often lack selectivity in treatment, using platinum-based drugs combined with etoposide or taxane, leading to toxicity issues that limit their effectiveness.
- * Research indicates that the transcription factor Pax5 plays a crucial role in promoting neuronal characteristics in t-NEPC, and its depletion may enhance the sensitivity of these cells to taxane therapies like docetaxel.