Publications by authors named "S S Lehrer"
Background: Infections, including bacterial pathogens, have been implicated in Alzheimer's disease (AD) risk. Klebsiella pneumoniae (K. pneumoniae) is a common hospital-acquired pathogen associated with significant inflammation, which may contribute to neurodegeneration.
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- Calcium channel blockers, specifically amlodipine, have been found to increase the risk of developing primary open-angle glaucoma (POAG) by 23%, prompting a study to further explore this association and its genetic factors.
- An analysis using MedWatch and UK Biobank data revealed that amlodipine use was linked to a significant rise in POAG prevalence and identified specific genetic polymorphisms (GAS7, CDKN2B-AS1, SIX6) that contribute to this risk.
- The study concluded that while amlodipine is commonly used for hypertension, its potential connection to POAG emphasizes the need for healthcare providers to consider alternative medications to minimize this risk.
Article Synopsis
- The APOE gene is known to be linked to Alzheimer's Disease (AD), but researchers are now looking at another gene called PILRA to see if it also affects the risk of AD.* -
- The study found that men with a specific genetic change (called rs1859788) were less likely to have AD, especially those who carried the ApoE ε4 version of the gene.* -
- The researchers discovered that PILRA might be important for understanding AD, and it may also be connected to a type of anemia, which adds to the complicated relationship between genes and Alzheimer's.*