[The dynamics of hemodynamic, psychophysiological parameters and adaptive potential of men of working age engaged in water-cold hardening].

Unlabelled: The article shows the influence of repeated repetition of contrasting temperature effects on hemodynamic, psychophysiological parameters and the adaptive potential of men of working age.

Objective: To assess changes of hemodynamic and psychophysiological parameters, as well as the adaptive potential in healthy men of working age under the influence of repeated contrasting temperature exposures, the difference of which is about 70 °C.

Material And Methods: Blood pressure, heart rate and Luscher test were measured 20 minutes before and 20 minutes after repeated exposure of contrasting temperature changes (alternation of temperature cycles).

Effects of Temperature on the Ability of Metabolites from Permafrost Microorganisms to Activate the Synthesis of Systemic Cytokines by Mononuclear Cells.

The effects of metabolites of Bacillus sp. strain M3 and Bacillus megaterium strain 8/75-1 isolated from permafrost formations, as well as a medicinal Bacillus cereus strain IP5832 on the secretion of TNFα, IL-1β, and IL-10 by mononuclear cells of human peripheral blood depending on the temperature of bacteria culturing (-16oC, -5oC, and 42oC) were studied. Metabolites of 8/75-1 and M3 strains cultured at 42oC produced more potent stimulating effect on TNFα and IL-10 synthesis than metabolites from these bacteria cultured at -16oC and -5oC (p<0.

Reparation and Immunomodulating Properties of Bacillus sp. Metabolites from Permafrost.

An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp.

Effects of Secondary Metabolites of Permafrost Bacillus sp. on Cytokine Synthesis by Human Peripheral Blood Mononuclear Cells.

We studied the effects of secondary metabolites of Bacillus sp. isolated from late Neogene permafrost on secretion of proinflammatory (TNF-α, IL-1β, IL-8, IL-2, and IFNγ) and antiinflammatory (IL-4 and IL-10) cytokines by human peripheral blood mononuclear cells. It was found that metabolites of Bacillus sp.