Cholesterol-ester prevents lipoprotein core from solidifying: Molecular dynamics simulation.

As an important part of lipid metabolism the liver produces large particles called very low density lipoproteins, filled mostly with triglyceride and cholesterol esters mixture. A large percentage of the mixture composition components has a melting point above physiological temperature. Thus solid cluster formation or phase transition could be expected.

Usefulness of serum myeloperoxidase in prediction of mortality in patients with severe heart failure.

Background: Myeloperoxidase levels were shown to reflect endothelial dysfunction, inflammation, atherosclerosis and oxidative stress.

Objectives: To examine the role of circulating myeloperoxidase, a leukocyte-derived enzyme, as a predictor of mortality in patients with congestive heart failure.

Methods: Baseline serum MPO levels were measured in 285 consecutive CHF patients and 35 healthy volunteers.

[Hemodynamic changes in the greater and lesser circulations of patients with a mitral heart defect and primary pulmonary hypertension under the influence of differentiated treatment].

The state of the greater and lesser hemodynamics in patients with rheumatic mitral heart disease complicated by pulmonary hypertension was analyzed after treatment with peripheral vasodilators and hemosorption. It is suggested that inclusion of hemosorption in the treatment complex favoured reduction of the degree of pulmonary hypertension, improvement of the central hemodynamics which may be directly related to improvement of the rheological properties of the blood.