Publications by authors named "S S Kirakodu"
Aim: The clinical outcomes of a variety of surgical procedures highly depend on tissue repair and show high variability among patients. There is a gap in the literature on how the host inflammatory response, the microbiome, and the interplay between them can influence oral mucosa healing. In this pilot study, we aimed to evaluate the microbiome and biomarkers profiles in patients who had desired versus undesired wound healing in the palatal mucosa.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) is associated with cellular abnormalities, tissue and organ dysfunctions, and periodontitis. This investigation examined the relationship between the oral microbiome and salivary biomarkers in T2DM patients with or without periodontitis. This cohort (35-80 years) included systemically healthy non-periodontitis (NP; n = 31), T2DM without periodontitis (DWoP; n = 32) and T2DM with periodontitis (DWP; n = 29).
View Article and Find Full Text PDFArticle Synopsis
- This study aims to explore the salivary microbiome characteristics in Type 2 diabetes mellitus (T2DM) patients, particularly comparing those with periodontitis to those without it.
- Periodontitis is linked to T2DM, and understanding the differences in oral microbiomes could improve diabetes management and clinical outcomes for patients.
- Results indicated that T2DM patients with periodontitis have distinct microbial profiles and levels of specific salivary analytes, suggesting a unique relationship between oral health and diabetes complications.
Article Synopsis
- The study compares microbial and inflammatory profiles in periodontally and systemically healthy African American (AA) and Caucasian (C) individuals aged 5 to 25 years.
- Results show that AA individuals had greater probing depth, while C individuals had higher caries and DMFT indices, with notable differences in inflammatory markers and microbial profiles between the groups.
- The findings suggest that these distinct profiles may lead to varying susceptibility to oral diseases in AA and C individuals.
Unlabelled: The local gingival tissue environment with homeostasis and tissue-destructive events of periodontitis demonstrates major changes in histological features and biology of the oral/sulcular epithelium, fibroblasts, vascular cells, inflammatory cell infiltration, and alveolar bone.
Objective: This study used an experimental periodontitis model to detail the gingival transcriptome related to cell death processes of pyroptosis, necroptosis, ferroptosis, and cuproptosis.
Materials And Methods: Healthy Macaca mulatta primates stratified by age, ≤3 years (young), 7-12 years (adolescent), 12-15 years (adult), and 17-23 years (aged), provided gingival tissue biopsies for microarray analysis focused on 257 genes representative of the four cell death processes and bacterial plaque samples for 16S rRNA gene analysis.