Hypertension Self-Management Among African American Adults.

Unlabelled: Hypertension disproportionately affects African Americans, and adequate blood pressure (BP) control remains a challenge. Self-management of hypertension is critical for improving BP control and reducing hypertension-related morbidities.

Objectives: The objective of this study is to describe hypertension self-management (HTN-SM) behaviors and the relationship between HTN-SM and self-reported BP in middle- to older-aged African American adults.

Optimizing time in harness : factors associated with sonographic resolution of developmental dysplasia of the hip during Pavlik treatment.

Aims: The primary aims of this study were to determine the time to sonographic correction of decentred hips during treatment with Pavlik harness for developmental dysplasia of the hip (DDH) and investigate potential risk factors for a delayed response to treatment.

Methods: This was a retrospective cohort study of infants with decentred hips who underwent a comprehensive management protocol with Pavlik harness between 2012 and 2016. Ultrasound assessments were performed at standardized intervals and time to correction from centring of the femoral head was quantified.

Impact of polygeNic risk score for glaucoma on psycHosocial ouTcomes (INSiGHT) study protocol.

Glaucoma is the leading cause of irreversible blindness with early detection and intervention critical to slowing disease progression. However, half of those affected are undiagnosed. This is largely due to the early stages of disease being asymptomatic; current population-based screening measures being unsupported; and a lack of current efficient prediction models.

How to build the virtual cell with artificial intelligence: Priorities and opportunities.

Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIVC), a multi-scale, multi-modal large-neural-network-based model that can represent and simulate the behavior of molecules, cells, and tissues across diverse states. This Perspective provides a vision on their design and how collaborative efforts to build AIVCs will transform biological research by allowing high-fidelity simulations, accelerating discoveries, and guiding experimental studies, offering new opportunities for understanding cellular functions and fostering interdisciplinary collaborations in open science.

A Study of Alkene Disulfonoxylation.

We have developed convenient protocols for alkene disulfonoxylation, which involve stirring alkene substrate with a commercial I(III) oxidant and sulfonic acid in CHCl at ambient temperature. The reactions can be performed open to air without any special precautions to exclude moisture and, in most cases, deliver the products of vicinal disulfonoxylation. Where relevant, the reactions are stereospecific and furnish the products of -disulfonoxylation.