Publications by authors named "S S Kantak"
Article Synopsis
- Tissue factor (TF) is commonly overexpressed in various cancers and is linked to worse outcomes, making it a target for treatment using the anti-TF antibody-drug conjugate XB002.
- XB002 effectively delivers a cytotoxic agent specifically to TF-expressing tumors while avoiding unintended side effects such as bleeding, as shown by its ability to not disrupt coagulation pathways.
- In preclinical studies, XB002 demonstrated strong anti-tumor effects in multiple cancer types, leading to complete tumor regression in some models, and showed promising safety profiles in non-human primates, supporting further clinical development.
Article Synopsis
- Many individuals who have had a stroke struggle to use their affected arm effectively even though they have the capability, a situation known as arm nonuse.
- *A study investigated how cognitive demand affects arm choice and motor performance in stroke patients using a virtual reality task that simulates real-life activities.
- *Results revealed that higher cognitive loads led to poorer performance with the affected arm, slower movements, and increased difficulty in reaching, highlighting the influence of cognitive factors on arm usage in daily life for stroke survivors.*
Background: Improvement of functional movements after supratentorial stroke occurs through spontaneous biological recovery and training-induced reorganization of remnant neural networks. The cerebellum, through its connectivity with the cortex, brainstem and spinal cord, is actively engaged in both recovery and reorganization processes within the cognitive and sensorimotor systems. Noninvasive cerebellar stimulation (NiCBS) offers a safe, clinically feasible and potentially effective way to modulate the excitability of spared neural networks and promote movement recovery after supratentorial stroke.
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- The study investigates how the perception of task goals affects motor performance and coordination during bimanual tasks in individuals with unilateral strokes compared to neurotypical controls.
- Participants completed bimanual reaching tasks under two different goal conditions: dual-goal (independent targets) and common-goal (single target), with findings showing improved spatial coordination across all groups in the common-goal condition.
- Additionally, it was found that sex influences movement characteristics, as female stroke survivors exhibited longer movement times and larger deviations during tasks, particularly in the left-hemisphere damage group.
Background: Unilateral stroke leads to asymmetric deficits in movement performance; yet its effects on naturalistic bimanual actions, a key aspect of everyday functions, are understudied. Particularly, how naturalistic bimanual actions that require the two hands to cooperatively interact with each other while manipulating a single common object are planned, executed, and coordinated after stroke is not known. In the present study, we compared the anticipatory planning, execution, and coordination of force between individuals with left and right hemisphere stroke and neurotypical controls in a naturalistic bimanual common-goal task, lifting a box.
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