[Changes in the clinical and immunological indices of patients with disseminated sclerosis being treated with prednisolone].

The authors examined clinically and immunologically 60 patients with multiple sclerosis. One group (30 patients) received prednisolone in the complex treatment while the second group (30 patients) received only complex treatment. A control group of 20 healthy persons was examined.

[The effect of prednisolone on the immunoglobulin content of the blood in patients with disseminated sclerosis].

The authors examined the dynamics of IgA, IgM, IgG in the blood of 100 patients with multiple sclerosis. Of them 50 patients received complex treatment in combination with prednisolone. Comparison of indices of concentration of serum immunoglobulins revealed a distinct reduction of their level of all classes in patients with multiple sclerosis, especially in those receiving prednisolone.

[Disordered lipid peroxidation and ATPase activities in patients with disseminated sclerosis].

Changes of ATP-ase activity and accumulation of lipid peroxidation products in patients with multiple sclerosis depended on the clinical course of the disease. Exacerbation is accompanied by an increased activity of Mg2(+)-dependent ATP-ase and reduction of Ca2(+)-dependent ATP-ase in the leucocytes. These changes were not revealed during remission.

[Folic acid in the combined treatment of patients with disseminated sclerosis and chronic gastritis].

Folic acid was used for the complex treatment of patients with multiple sclerosis. The doses employed were 200-300 mcg daily. It was established that folic acid improved the reparative processes in the gastric mucosa and produced a pronounced therapeutic effect on the neurological status of the patients, favoured improvement of their general condition.

[Primary disability due to tuberculosis].

The social and clinical background of 1,043 tuberculosis patients newly recognized as disabled was studied. A complex study of the interrelation between tuberculosis-induced disability and medical and social factors was undertaken. Ineffective treatment proved to be the leading cause of disability, associating with untimely detection of the disease in 19.