Real-world characteristics and outcomes of patients with multiple myeloma receiving second-line treatment in England.

Introduction: Despite recent advances in first-line therapies for multiple myeloma (MM), most patients relapse or become refractory, underscoring the need for effective second-line (2L) regimens for relapsed/refractory MM (RRMM).

Methods: This study describes the real-world baseline characteristics, treatment patterns and clinical outcomes of adult patients diagnosed with MM between 2013 and 2020 using data collated by the National Cancer Registration and Analysis Service (NCRAS) of the National Health Service in England. The study cohorts were broadly aligned to the eligibility criteria of the ongoing DREAMM-7 (D7) and DREAMM-8 (D8) clinical trials.

Biphasic Cuirass Ventilation for Airway Surgeries: A Comprehensive Review.

Airway surgeries pose great challenges for the anesthesiologists as the airway is shared by them and the surgeon. It is of paramount importance to have control of the airway during such surgeries. Many techniques have been employed to provide uninterrupted oxygenation to the patient with or without the presence of a definitive airway.

Medical Gaze Sans Bioethics: Revisiting Enslaved Black Women's Medical Bondage in Behind the Sheet.

The birth of modern gynecology in the USA is preceded by experimental exploitations of Black women's bodies in the mid-nineteenth century, entailing a long-drawn extraction of "reproductive knowledge" from enslaved patients. Charly Evon Simpson's Behind the Sheet (2019) stages the history of medical bondage of Black enslaved women in antebellum South, reconstructing the events that led to the surgical innovation for vesico-vaginal fistula. Scrutinizing Simpson's dramatization of the event, this paper prompts inquiries into the interplay of power and consent between the physician and the enslaved patient in plantation healthcare, highlighting the need to reexamine bioethical principles.

An analysis of availability and implications of unlabeled retracted articles on Sci-Hub.

Background: Researchers are increasingly accessing scientific articles through unauthorized websites like Sci-Hub. Sci-Hub contains retracted articles, including those which are not labelled as retracted, and this is a potential threat to academic research.

Methods: This study analyses the extent of the availability of retracted articles within the Sci-Hub, particularly focusing on the presence of unlabeled retracted articles (URA) which may inadvertently be used in subsequent research, thus propagating flawed findings.

Endocrown: A Minimally Invasive Alternative to Conventional Fixed Prosthesis.

Endodontically treated teeth with compromised coronal tooth structure often require core build-ups with the support of radicular posts. In certain cases, the traditional post and core approach may not be possible due to various anatomical and clinical contraindications. Such cases require more meticulous planning and alternative treatment approaches for successful outcomes.