Publications by authors named "S S Howards"
Increasing survival rates of children following cancer treatment have resulted in a significant population of adult survivors with the common side effect of infertility. Additionally, the availability of genetic testing has identified Klinefelter syndrome (classic 47,XXY) as the cause of future male infertility for a significant number of prepubertal patients. This study explores new spermatogonia stem cell (SSC)-based fertility therapies to meet the needs of these patients.
View Article and Find Full Text PDFKlinefelter Syndrome (KS) is characterized by a masculine phenotype, supernumerary sex chromosomes (47, XXY), and impaired fertility due to loss of spermatogonial stem cells (SSCs). Early testicular cryopreservation could be an option for future fertility treatments in these patients, including SSCs transplantation or spermatogenesis. It is critically essential to adapt current SSCs propagation systems as a fertility option for KS patients.
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- The study aimed to investigate the prevalence of spermatogonia in adult males with Klinefelter syndrome (KS) by using specific immunohistochemical markers (MAGE-A4 and UCHL1) and comparing these results with traditional histologic analysis (H & E staining).
- A total of 79 adult subjects with KS and 12 control subjects were examined, focusing on tissue samples obtained from testicular biopsies aimed at sperm recovery for reproduction.
- The main outcome measured was the presence of undifferentiated spermatogonia in the tissue samples, along with supportive data on various morphometric and clinical parameters, to better understand the reproductive potential in KS subjects.
Background: Klinefelter syndrome (KS) has been defined by sex chromosome aneuploidies (classically 47, XXY) in the male patient. The peripubertal timeframe in KS patients has been associated with the initiation of progressive testicular fibrosis, loss of spermatogonial stem cells (SSC), hypogonadism and impaired fertility. Less than half of KS patients are positive for spermatozoa in the ejaculate or testis via semen analysis or testicular sperm extraction, respectively.
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