Publications by authors named "S S Gupte"
GDM is an increasing global concern, with its etiology not fully understood, though altered placental function is likely to play a role. Placental angiogenesis, essential for sufficient blood flow and nutrient exchange between mother and fetus, may be affected by GDM. However, the role of angiogenic markers in GDM remains unclear.
View Article and Find Full Text PDFAim: This study aims to examine the gene expression and DNA methylation patterns of angiogenic factors in the placentae of Indian women who underwent assisted reproductive technology (ART) procedures and their association with maternal one-carbon metabolites and birth outcome.
Methods: Placental gene expression and DNA methylation of angiogenic factors (, , , ) in Indian women who underwent ART procedures ( = 64) and women who conceived naturally (Non-ART) ( = 93) was investigated using RT-qPCR and Epitect Methyl-II PCR assay kits. Maternal plasma one-carbon metabolites were assessed by CMIA technology.
Article Synopsis
- WAGR syndrome includes Wilms tumor risk, absence of irises, genital/urinary abnormalities, and growth delays; it's linked to deletions on chromosome 11.
- Key symptoms can be undescended testes or nystagmus, which may alert doctors to aniridia.
- Genetic diagnosis methods include chromosomal microarray and MLPA, with the syndrome typically inherited in an autosomal dominant fashion but often arising from new mutations.
Article Synopsis
- * A six-year-old girl showed symptoms like drowsiness, difficulty breathing, and high blood sugar, along with severe hypertriglyceridemia and metabolic acidosis.
- * Treatment followed ISPAD guidelines, involving intravenous fluids, potassium supplementation, and insulin therapy to stabilize her condition.
Article Synopsis
- The study explored how early pregnancy affects psychological well-being and sleep quality among 325 pregnant women in urban and rural areas of Pune, India, noting a significant prevalence of distress and poor sleep.
- Results showed that 37.5% of women experienced prenatal distress, with a higher prevalence (40%) in rural areas and a strong link between high distress and poor sleep quality.
- Factors like rural living, low BMI, vomiting episodes, and overall poor sleep were identified as contributors to higher prenatal distress, highlighting the need for early intervention strategies to improve outcomes for mothers and infants.