Publications by authors named "S S Grove"
Article Synopsis
- Immune checkpoint blockade (ICB) can induce tumor ferroptosis, but many patients don't respond because tumors evade this process within the tumor microenvironment (TME).
- Researchers found that SLC13A3 acts as a transporter for itaconate in tumor cells, contributing to resistance against ferroptosis, which weakens tumor immunity and reduces ICB effectiveness.
- Targeting SLC13A3 through various methods, like genetic alteration or using a specific inhibitor, can sensitize tumors to ferroptosis, slow down tumor growth, and enhance the effectiveness of ICB treatments, highlighting SLC13A3 as a potential target for cancer therapy.
Objective: In this study the authors assessed the ability of Chat Generative Pretrained Transformer (ChatGPT) 3.5 and ChatGPT4 to generate readable and accurate summaries of published neurosurgical literature.
Methods: Abstracts published in journal issues released between June 2023 and August 2023 (n = 150) were randomly selected from the top 5 ranked neurosurgical journals according to Google Scholar.
Article Synopsis
- This study examines genetic variation in salmonid alphavirus-3 (SAV3) during infections in Atlantic salmon and brown trout using cohabitation challenges.
- Researchers collected heart samples at 2, 4, and 8 weeks post-infection and analyzed the SAV3 genome using PCR and Nanopore sequencing, revealing numerous single nucleotide variants (SNVs) and deletions.
- Results indicated that SAV3 exhibited greater genomic variation in brown trout compared to Atlantic salmon late in the infection, highlighting the potential for diverse viral mutations during RNA virus infections.
Background: While voluntary medical male circumcision (VMMC) reduces the risk of HIV transmission by 60%, circumcision coverage falls short of the UNAIDS 90% VMMC target. We investigated whether behaviorally informed message framing increased demand for VMMC.
Setting: Adult users of the MoyaApp, a data-free application in South Africa, who viewed a form designed to generate interest in VMMC from August 2022 to November 2022.
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolerance checkpoint. We showed that genetic deficiency of B7-H4 resulted in immune activation and fetal resorption in allogeneic pregnancy models.
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