Dimethyl nitrosamine (DMN), a potent hepatotoxin, exerts carcinogenic effects and induces hepatic necrosis in experimental animals via CYP2E1 metabolic activation, and generation of reactive oxygen species (ROS). Protocatechuic acid (PCA), a plant-based simple phenolic compound and potent antioxidant, has been shown to affect the development of neoplasia in the rat liver and inhibit the initiation or progression phases of most cancers. In this study, the modulatory effects of PCA on DMN-induced hepatotoxicity, oxidative stress, inflammation, and selected phase I xenobiotic metabolizing enzymes were investigated in male Wistar rats.
View Article and Find Full Text PDFIntroduction: The study determined the proportion of rural parents with good knowledge about and good attitude toward children making their first dental visit by their first birthday. It also assessed the association among age, sex, level of education, past dental visits of parents, and knowledge about and good attitude toward children making their first dental visit by their first birthday.
Materials And Methods: This was a cross-sectional study that collected data from 115 parents in a rural setting using an interviewer-administered questionnaire.
Background: Feedback is central to a quality medical and dental education in promoting self-directed learning and enhance progressive sharpening of trainees' skills, which are applicable in orthodontics. Hence, orthodontic educators must be conversant with the subject of feedback. There is insufficient information concerning this at the moment.
View Article and Find Full Text PDFEur J Paediatr Dent
September 2015
Aim: To assess the standards of care given to children who sustain traumatic dental injuries (TDI) in Nigerian primary schools.
Study Design: cross-sectional study. Public and private schools were selected from the Southern geopolitical zones in Nigeria.