[Collonization of intestinal tract of leukaemia patients with Candida and development of systemic candidemia].

The aim of the research was to study the peculiarities of colonization of intestinal tract by Candida - in children with leukemia. It was found that in 32 out of 54 patients with leukaemia the quantity of intestinal KOE Candida in 1 g feces was correlated with the incidence of candidemia. The quantity of intestinal KOE/g Candida was higher in patients receiving antileukemic chemotherapy and antibacterial antibiotics than in normal subjects in patients with The quantity of Candida KOE/g feces was >10(5) cells per 1g of substrate.

[Assessment of endogenous intoxication and thrombocyte functions in beta-thalassemia].

The parameters of humeral immunity and of the aggregation function of blood platelets were comparatively analyzed in 11 healthy and 26 children with beta-thalassemia; 18 of them had beta-thalassemia of the homozygous type (spleen was extracted in 8 children, and it remained intact in 10 children). It was demonstrated that there was an increased quantity of antibodies to blood platelets and an increased quantity of large, medium-size and small circulating immune complexes in patients with beta-thalassemia and especially in those, who did not undergo splenectomy; there was also an increased quantity of immunoglobulins of classes A, M, and G, a reduced total activity of the complement and a high parameter of the degree of endogenous intoxication, i.e.

[Study of the spectrum of rabbit myocardium nuclear DNAases using models of ischemia and diabetes mellitus].

There were alterations in the spectrum of nuclear endo-DNAases in the rabbit myocardium on experimental models of diabetes mellitus and other diseases where the perfused heart was involved i.e. disappearance of the enzyme with 130 kDa from the control extracts was followed by a great increase in the content of low molecular forms in the nuclear preparations obtained from the ischemic heart, as well as that with 145 kDa in all the abnormalities under study.

[Nuclear endo-DNAse from rabbit myocardium in ischemia and diabetes mellitus].

The activity of deoxyribonucleases was altered in the myocardium of New Zealand rabbits under normal conditions, in diabetes mellitus as well as in various experiments, where model heart perfusion was carried out using media of various ion composition and pH value. Studies of Ca2+, MG(2+)- dependent deoxyribonuclease from myocardial nuclear extracts exhibited that protective cell mechanisms appear t be induced at the first steps of tissue ischemic impairments as well as that diabetes decreased cardiac sensitivity to ischemia.