Exploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development.

Traditional small molecule drugs often target protein activity directly, but challenges arise when proteins lack suitable functional sites. An alternative approach is targeted protein degradation (TPD), which directs proteins to cellular machinery for proteolytic degradation. Recent studies have identified additional E3 ligases suitable for TPD, expanding the potential of this approach.

Identifying Trajectories of Change in Burnout Symptoms of Gaelic Games Athletes Over Two Consecutive Seasons.

Athlete burnout is conceptualized as an enduring multidimensional syndrome, and longitudinal research is essential to understanding its development over time. However, much of the existing work has been limited to a small number of timepoints (≤3) or short intervals between waves (≤3 weeks), which fail to account for the chronic and complex nature of the syndrome. This study aimed to address these limitations by tracking burnout in adult athletes at 6 timepoints over a 21-month period for the first time.

"Art is just something that makes people heal"-a qualitative investigation of tattoo artists' perspectives on cancer survivorship therapeutic tattoos.

Purpose: Many cancer treatments can lead to a disrupted body image and identity. One intervention to address these outcomes is therapeutic tattooing. However, despite the wide dissemination of this practice for cancer survivors (CSs), current research on it is lacking.

'They think we're just in God's waiting room': A discursive study on identity aloneness in stroke survivors.

This paper examines the rhetorical strategies used by stroke survivors to attend to identity aloneness, a phenomenon in which individuals experience a sense of disconnect from others as a consequence of identity change, for which stroke is known as an antecedent. Three stroke survivors, and their spouses, were interviewed about their stroke, social support, and experiences with loneliness and identity change. The data was transcribed using a simplified version of the Jeffersonian method and analysed using a critical discursive psychological approach.