MONSTROUS: a web-based chemical-transporter interaction profiler.

Transporters are membrane proteins that are critical for normal cellular function and mediate the transport of endogenous and exogenous chemicals. Chemical interactions with these transporters have the potential to affect the pharmacokinetic properties of drugs. Inhibition of transporters can cause adverse drug-drug interactions and toxicity, whereas if a drug is a substrate of a transporter, it could lead to reduced therapeutic effects.

Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation.

Uterine receptivity is essential for successful implantation. In mice, uterine receptivity begins with the secretion of LIF from uterine glands stimulated by estrogen on the morning of day 4 pregnancy. We hypothesize that gland readiness for estrogen stimulation is indispensable for uterine receptivity.

Reusable CuO NPs Catalyzed Chemodivergent Transfer Hydrogenation of Azoarenes to Hydrazoarenes and Aniline Derivatives.

The selective synthesis of different products from a substrate employing a single catalyst by altering the reaction conditions is challenging. Herein, easy-to-synthesize and cheap CuO NPs catalyzed chemodivergent transfer hydrogenation (TH) of azoarenes to hydrazoarene and aniline derivatives using ammonia borane (AB) under mild condition is disclosed. The practical applicability of the protocol was demonstrated by gram-scale synthesis of hydrazo and aniline derivatives as well as by the reduction of few commercially used dyes such as methyl red, sudan I, sudan III and solvent yellow 7.

Factors influencing health promotion behavior on puerperal sepsis among postpartum mothers.

Puerperal sepsis is accountable for maternal death worldwide. The health promotion behaviour of postpartum mothers may contribute to preventing puerperal sepsis, which would promote maternal health. The study aims to identify the factors influencing health promotion behaviour on puerperal sepsis among postnatal mothers.

Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes.

Free fatty acids like palmitic acid (PA) are elevated in obesity and diabetes and dysregulate monocyte and macrophage functions, contributing to enhanced inflammation in these cardiometabolic diseases. Epigenetic mechanisms regulating enhancer functions play key roles in inflammatory gene expression, but their role in PA-induced monocyte/macrophage dysfunction is unknown. We found that PA treatment altered the epigenetic landscape of enhancers and super-enhancers (SEs) in human monocytes.