Screening for Depression in Caregivers of Children with Developmental Disabilities: A Quality Improvement Initiative.

Introduction: Screening for depression in caregivers of children with developmental disabilities is not routine, representing missed opportunities for support.

Method: A quality improvement project was initiated in our pediatric clinic. Root causes of limited screening included unclear guidelines for support, caregiver perception that help is unavailable, and lack of a quick screening tool.

Sdd3 regulates the biofilm formation of via the Rho1-PKC-MAPK pathway.

, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. In this study, we conducted a genetic screen to identify novel genes that regulate biofilm formation in .

Human macrophage response to the emerging enteric pathogen : Inflammation, apoptosis, and downregulation of histones.

This study investigated the pathogenic mechanisms of in macrophages. THP-1 derived macrophages were used as a human macrophage model and were treated with strain AS1 isolated from intestinal biopsies of an IBD patient, or strain K-12. RNA was extracted and subjected to RNA sequencing and comparative transcriptomic analyses.

High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.

RNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral RNA. We identified potent lipophilic small interfering RNA (siRNA) conjugates targeting highly conserved regions of SARS-CoV-2 outside of the spike-encoding region capable of achieving ≥3-log viral reduction. Serial passaging studies demonstrated that a two-siRNA combination prevented development of resistance compared to a single siRNA approach.