Low catalyst loading enabled organocatalytic synthesis of chiral bis-heterocyclic frameworks containing pyrazole and isoxazole.

The organocatalytic asymmetric synthesis of enantiopure bis-heterocyclic molecules containing pyrazole and isoxazole under mild reaction conditions has been reported a low-catalyst loading Michael addition reaction of pyrazolyl nitroalkenes with 1,3-dicarbonyl derivatives. 4-Substituted pyrazole derivatives were obtained in 60-87% yields and with 82-97% ee. These pyrazolyl derivatives are further transformed into chiral bis-heterocyclic derivatives in up to 82% yields and up to 99% ee.

Toxic effects of purified phenolic compounds from Acacia nilotica against common cutworm.

Phenolics are the most abundant secondary metabolites of plants that are widely distributed in the plant kingdom. In the last few years, the development and identification of phenolic compounds from various plants have become a major area of the environment and health-related research. In the present study, different phenolic compounds were purified from the bark of the medicinally important plant Acacia nilotica which is rich in polyphenols and were evaluated for their insecticidal potential against a polyphagous pest, Spodoptera litura (Fab.

Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles.

Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated under basic conditions. This intermediate can readily react with other nucleophilic reagents to obtain C-3 substituted indole derivatives. In the last few years, a plethora of exciting synthetic applications of this substrate have been exploited.

Recent advances in the catalytic synthesis of 3-aminooxindoles: an update.

3-Substituted-3-aminooxindoles are versatile scaffolds and they are common core structural motifs found in many natural products and biologically active compounds. In the last few years, a variety of synthetic methodologies have been developed for the synthesis of this moiety. In this review, we are presenting the recent advances in the catalytic synthesis of 3-aminooxindole derivatives.