An Analysis and Validation Questionnaire-Based Survey in Hindi on the Psychosocial Effects of Pre-Treatment Aesthetic Dentistry from Delhi NCR.

Purpose: One of the many tools used to assess several facets of oral health-related quality of life in individuals with dental aesthetic deficits is the Psychosocial Impact of Dental Aesthetic Questionnaire (PIDAQ). The PIDAQ, however, was created for orthodontic patients, who usually possess different aesthetic concerns than those receiving prosthodontic treatment.

Aim: Analyzing and confirming in Hindi the psychosocial effects of pretreatment dental aesthetics among patients in Delhi NCR is the study's main objective.

Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer's pathology stages.

The locus coeruleus (LC) has been identified as a site that develops phosphorylated tau pathology earlier than cerebral cortex. We present data using high-resolution postmortem MRI and validated tau histopathology in controls and the earliest Braak and Braak (BB) stages (BBI-BBII) in LC. The high-resolution ex vivo MRI provides a 3D volume (quantitative), while the histology reveals tau specificity and severity burden (semi-quantitative).

Perceptions of hearing loss and hearing technology among the general public and healthcare providers: a scoping review.

Objectives: Synthesise literature related to perceptions of hearing loss and hearing technology (hearing aids, cochlear implants) among the general public and healthcare providers who do not specialise in ear and hearing care.

Design: Scoping review.

Data Sources: We searched three databases (PubMed, Scopus, Ovid Medline) in August 2023 for peer-reviewed articles from inception to 2023.

Deciphering optimal molecular determinants of non-hemolytic, cell-penetrating antimicrobial peptides through bioinformatics and Random Forest.

Antimicrobial peptides (AMPs) are promising molecules for combating resistant pathogens, offering several advantages like broad-spectrum effectiveness and multi-targeted action. While most AMPs exhibit membranolytic activity similar to hemolytic peptides (HPs), some act by entering cells like cell-penetrating peptides (CPPs). The toxicity of AMPs towards the host is the major hurdle in their development and application.

Access to Ear and Hearing Care Globally: A Survey of Stakeholder Perceptions from the Lancet Commission on Global Hearing Loss.

Objective: Characterize global access to ear and hearing care (EHC) to inform future policy recommendations.

Study Design: Survey using convenience sampling.

Setting: Subjects were surveyed via contact lists of the World Health Organization, Global Otolaryngology-Head and Neck Surgery Initiative, and Global HEAR Collaborative.