Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy.

Purpose: Diabetic retinopathy (DR) is usually diagnosed many years after diabetes onset. Indeed, an early diagnosis of DR remains a notable challenge, and, thus, developing novel approaches for earlier disease detection is of utmost importance. We aim to explore the potential of texture analysis of optical coherence tomography (OCT) retinal images in detecting retinal changes in streptozotocin (STZ)-induced diabetic animals at "silent" disease stages when early retinal molecular and cellular changes that cannot be clinically detectable are already occurring.

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).

Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect.

Sugar Cane ( L.) Waste Synthesized Si,N,S-Carbon Quantum Dots as High-Performance Corrosion Inhibitors for Mild Steel in Hydrochloric Acid.

This work reports the obtention of Si,N,S-CQDs from sugar cane bagasse and their inhibitory action on the mild steel corrosion in 1 mol L HCl solution. The CQDs were successfully obtained and characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, Dynamic light scattering, Raman, and UV-vis techniques, also showing endogenous self-doping. The anti-corrosive activity of CQDs was investigated by gravimetric tests, potentiodynamic polarization curves, electrochemical impedance measurements, atomic force microscopy, and scanning electron microscopy.

Phytotoxicity Study of (Amino)imidazo[1,2-]pyridine Derivatives Toward the Control of , , and Weeds.

In this work, several imidazo[1,2-]pyridines were synthesized through the Groebke-Blackburn-Bienaymé three-component reaction (GBB-3CR), and their phytotoxicity was evaluated by the influence on the growth of wheat coleoptiles and three important agricultural seeds (, , and ) at test concentrations of 1000, 300, 100, 30, and 10 μM. A structure-activity relationship was established, showing the importance of halogen groups at the position of the attached aromatic ring and the presence of a cyclohexylamine group for greater activity. Post-modification of some GBB-3CR adducts was carried out, leading to imidazo[1,2-]pyridine-tetrazole hybrids, which were also evaluated in these bioassays.