Publications by authors named "S S Buys"
Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years.
Cancer Epidemiol Biomarkers Prev
January 2025
Article Synopsis
- The study investigates the relationship between recreational physical activity (RPA) in adolescence and early adulthood and breast cancer (BC) risk in women under 40 years old, using data from a large international family cohort.
- Results indicate that higher levels of RPA are linked to reduced BC risk, with a 12% lower risk during adolescence and a 16% lower risk during early adulthood for women in the highest activity quartiles.
- The findings suggest that encouraging more physical activity in young women could be a crucial strategy for lowering the increasing incidence of breast cancer in this age group.
Article Synopsis
- The study investigates the relationship between hormonal contraceptive use and breast cancer risk in both unaffected women and mutation carriers.
- Out of the participants, it was found that hormonal contraceptive use was linked to a higher breast cancer risk in mutation carriers, particularly with longer duration of use.
- The findings suggest that decisions regarding hormonal contraceptive use for women with genetic mutations should consider individual risk factors and benefits.
Importance: Increasing numbers of unaffected individuals could benefit from genetic evaluation for inherited cancer susceptibility. Automated conversational agents (ie, chatbots) are being developed for cancer genetics contexts; however, randomized comparisons with standard of care (SOC) are needed.
Objective: To examine whether chatbot and SOC approaches are equivalent in completion of pretest cancer genetic services and genetic testing.
Importance: Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in BC risk is critical to understanding BC causes and for developing effective risk-based screening guidelines.
Objective: To examine the association between pregnancy-related factors and BC risk, including modification by a of BC where scores are based on age and BC family history.
Purpose: Assessing risk of recurrence for nonmetastatic triple-negative breast cancer (TNBC) is a key determinant of therapeutic strategy. The best predictor of recurrence risk is failure to achieve a pathologic complete response after preoperative chemotherapy, but it imperfectly correlates with the definitive end points of relapse-free and overall survival (OS). The inability to accurately predict recurrence has led to increasingly toxic treatment regimens for patients with early-stage TNBC.
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