Shoshin Beriberi in a Child With Intestinal Failure: A Case Report.

Background: Acute illness states with increased metabolic demand can precipitate severe thiamine deficiency if physiologic needs exceed endogenous stores and supplementation. Patients with preexisting risk factors such as parenteral nutrition (PN) dependence, eating disorders, gastrointestinal disorders, or surgeries are especially vulnerable.

Case Summary: A 9-year-old girl with short bowel syndrome receiving long-term PN, including standard thiamine supplementation, presented with refractory shock following aspiration.

Implementation of type 1 diabetes genetic risk screening in children in diverse communities: the Virginia PrIMeD project.

Background: Population screening for risk of type 1 diabetes (T1D) has been proposed to identify those with islet autoimmunity (presence of islet autoantibodies). As islet autoantibodies can be transient, screening with a genetic risk score has been proposed as an entry into autoantibody testing.

Methods: Children were recruited from eight general pediatric and specialty clinics across Virginia with diverse community settings.

Analytical fitting of -ray photopeaks in germanium cross strip detectors.

In an ideal germanium detector, fully-absorbed monoenergetic -rays will appear in the measured spectrum as a narrow peak, broadened into a Gaussian of width determined only by the statistical properties of charge cloud generation and the electronic noise of the readout electronics. Multielectrode detectors complicate this picture. Broadening of the charge clouds as they drift through the detector will lead to charge sharing between neighboring electrodes and, inevitably, low-energy tails on the photopeak spectra.