Publications by authors named "S S Bhujbal"
JNK3, a brain-specific stress-activated protein kinase, plays a critical role in Alzheimer's disease pathogenesis through phosphorylation of Tau and APP. This study aimed to develop selective JNK3 inhibitors based on a pyrazole scaffold, focusing on (E)-1-(2-aminopyrimidin-4-yl)-4-styryl-1H-pyrazole-3-carboxamide derivatives. Through systematic structural modifications and extensive SAR analysis, we identified compounds 24a and 26a as highly potent JNK3 inhibitors, with IC values of 12 and 19 nM, respectively.
View Article and Find Full Text PDFCorrection for 'An NNN Pd(II) pincer complex with 1,1-diaminoazine: a versatile catalyst for acceptorless dehydrogenative coupling reactions' by Aabid A. Wani , , 2024, https://doi.org/10.
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- The text discusses a new method for activating distal C-H bonds to create benzofulvenes, which are compounds formed through a [3 + 2] reaction involving palladium catalysis, overcoming traditional bond activation challenges.
- This innovative approach involves concurrent activation of both β-C(benzylic)-H and δ-C(aryl)-H bonds and leads to the formation of novel chemical entities with promising anticancer properties.
- In studies, these new compounds were found to effectively target oral squamous cell carcinoma (OSCC) by arresting the cell cycle at the S-phase and activating various apoptosis pathways, indicating their potential as effective chemotherapy options.
An azine-based, non-palindromic, neutral NNN-pincer ligand was synthesised in a single step with an yield of 85%. The palladation of the ligand, using Pd(OAc), was performed in acetonitrile at room temperature to obtain the pincer complex in 88% yield through a simple, cost-effective, and straightforward synthetic procedure. The structure of the complex was confirmed by H NMR, C NMR, FT-IR, and mass spectrometry.
View Article and Find Full Text PDFA stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed to assay tonabersat and assess its stability in pharmaceutical formulations. Chromatographic separation was achieved using a Kinetex® C18 column (2.6 µm, 150 x 3 mm, 100 Å) at 50 °C, with a 20 µL injection volume.
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