[Personalized character of toxic effects through mass nonlethal poisoning by phenazepam and other psychoactive substances].

Over several months, 14 people were admitted in 6 hospitals with severe symptoms of intoxication with psychoactive substances as a result of mass poisoning. All symptoms occurred after taking a drink that contained crushed phenazepam tablets. Samples of blood (=10) and urine (=6) taken from 14 sufferers for forensic, chemical and toxicological examination were analyzed using the HPLC-MS/MS method.

[Features of obtaining of biological material during emergency incidents with human victims, its referral and forensic chemical examination].

In this article, we consider features of the referral of biological material and assessment of medical and legal chemical researches at emergencies of technogenic character, plane crashes, the fires with the numerous human victims. Practical recommendations on obtaining of biological material for a research on volatile organic compounds, including ethyl alcohol and its metabolites, volatile products of burning, including monoxide of carbon and cyanides are made. Features and the recommended order of conducting judicial and chemical examination at emergencies are designated.

[The study of fenspiride: goals and objectives for chemical and toxicological studies].

The purpose of this work is to study fenspiride for the purposes and tasks of chemical and toxicological research. The technique of chemical-toxicological study of fenspiride in urine by preliminary and confirming methods is proposed. The authors proposed a method of thin - layer chromatography in the solvent system of acetone - 25% ammonia solution (9:1) in a preliminary study of fenspiride.

[The detection of the 25B-NBOMe derivative of phenylethylamine in the biological material].

This article is focused on the conditions for the detection and identification of 2-[4-bromo-2.5-dimethoxyl]-N-[(2-methoxyphenyl)methyl] ethamine (25B-NBOMe) and its major metabolites by the combination of the HPLC/MS/MS techniques. The high-resolution mass spectra obtained with the use of a linear ion trap are described.

[The development and validation of the method for the identification of ethyl glucuronide and ethyl sulfate as the markers of the consumption of ethyl alcohol during one's lifetime].

The objective of the present study was the development and validation of the rapid reproducible method for the identification of ethyl glucuronide and ethyl sulfate allowing to store and transport the study specimens without the loss of the substances of interest by placing the samples on the paper. We have developed the validated technique for the detection and quantitative determination of ethyl glucuronide and ethyl sulfate in the cadaveric blood and urine by means of low-resolution tandem mass-spectroscopy with the use of deuterated derivatives of these substances as the internal standards. The low threshold for quantitative determination of both above substances is 50 ng/ml for the blood and 100 ng/ml for the urine.