Premature cognitive decline in a mouse model of tuberous sclerosis.

Little is known about the influence of (impaired) neurodevelopment on cognitive aging. We here used a mouse model for tuberous sclerosis (TS) carrying a heterozygous deletion of the Tsc2 gene. Loss of Tsc2 function leads to mTOR hyperactivity in mice and patients.

Representational maps in the brain: concepts, approaches, and applications.

Neural systems have evolved to process sensory stimuli in a way that allows for efficient and adaptive behavior in a complex environment. Recent technological advances enable us to investigate sensory processing in animal models by simultaneously recording the activity of large populations of neurons with single-cell resolution, yielding high-dimensional datasets. In this review, we discuss concepts and approaches for assessing the population-level representation of sensory stimuli in the form of a representational map.

Validation of a German version of the Boredom Proneness Scale and the Multidimensional State Boredom Scale.

The scientific interest in boredom is growing over the past decades. Boredom has not only been linked to symptoms of psychopathology, but also shows a remarkable effect on individual behavior under healthy conditions. Current characterizations of boredom in humans mostly rely on self-report assessments which proved to faithfully reflect boredom in a vast range of experimental environments.

Modeling fashion as an emergent collective behavior of bored individuals.

Boredom is an aversive mental state that is typically evoked by monotony and drives individuals to seek novel information. Despite this effect on individual behavior, the consequences of boredom for collective behavior remain elusive. Here, we introduce an agent-based model of collective fashion behavior in which simplified agents interact randomly and repeatedly choose alternatives from a circular space of color variants.

Utilizing 2D-region-based CNNs for automatic dendritic spine detection in 3D live cell imaging.

Dendritic spines are considered a morphological proxy for excitatory synapses, rendering them a target of many different lines of research. Over recent years, it has become possible to simultaneously image large numbers of dendritic spines in 3D volumes of neural tissue. In contrast, currently no automated method for 3D spine detection exists that comes close to the detection performance reached by human experts.