Gold-catalyzed ethylene cyclopropanation.

Ethylene can be directly converted into ethyl 1-cyclopropylcarboxylate upon reaction with ethyl diazoacetate (NCHCOEt, EDA) in the presence of catalytic amounts of IPrAuCl/NaBAr (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene; BAr = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate).

Phosphine-functionalized NHC Ni(ii) and Ni(0) complexes: synthesis, characterization and catalytic properties.

Two families of nickel complexes bearing chelating diphenylphosphine-functionalized NHC ligands [Ni(ArNHCPPh)(allyl)]Cl 1a (Ar = Mes); 1b, (Ar = 2,6-iPr-CH) and [Ni(ArNHCPPh)(alkene)] 2a (Ar = 2,6-iPr-CH, alkene = styrene); 2b (Ar = 2,6-iPr-CH, alkene = diethyl fumarate) have been prepared and fully characterized. VT-NMR experiments in solution reveal that the allyl derivatives 1a-b are stereochemically nonrigid. The solid-state structure of the Ni derivative 2b is also reported.

The Elusive Palladium-Diazo Adduct Captured: Synthesis, Isolation and Structural Characterization of [(ArNHC-PPh )Pd(η -N C(Ph)CO Et)].

The first example of a diazo palladium adduct is reported. The complexes [(ArNHC-PPh )M(η -N C(Ph)CO Et)] (M=Ni, 3; M=Pd, 4; ArNHC-PPh =3-(2,6-diisopropylphenyl)-1-[(diphenylphosphino)ethyl]imidazol-2-ylidene) were prepared by ligand exchange with styrene-coordinated precursors [(ArNHC-PPh )M(styrene)] (M=Ni, 1; M=Pd, 2). Complex 4 was fully characterized, including X-ray analyses; this constitutes the first example of a diazo adduct compound with palladium, thereby closing the gap between Groups 8 and 10 regarding this type of compounds.

Impact of a Proprietary Standardized Olive Fruit Extract (SOFE) on Cardio-Ankle Vascular Index, Visual Analog Scale and C-Reactive Protein Assessments in Subjects with Arterial Stiffness Risk.

Introduction: The chemical components of olive fruit provide a wide range of cardiovascular benefits. Arterial stiffness is an important cardiovascular risk factor and can be assessed using the Cardio-Ankle Vascular Index (CAVI).

Objective: The objective of this study was to assess the impact of a proprietary standardized olive fruit extract (SOFE) in subjects at risk for arterial stiffness.

Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system.

Background: The nicotinamide adenine dinucleotide phosphate-dependent membrane protein 5α-reductase catalyses the conversion of testosterone to the most potent androgen - 5α-dihydrotestosterone. Two 5α-reductase isoenzymes are expressed in humans: type I and type II. The latter is found primarily in prostate tissue.